The Handan-Xingtai region is a major ore concentration area for large-scale skarn iron deposits in China, and ore prospecting in the deep and peripheral areas of existing mines constitutes the primary task at the current stage. The high-density and high-magnetic characteristics of iron ore targets relative to surrounding rocks provide crucial physical property support for delineating iron ore prospective areas using gravity and magnetic data. However, practical applications are still confronted with issues such as irrelevant signal interference, strong remanent magnetization, and non-uniqueness in interpretations. Based on high-resolution ground gravity and aeromagnetic data in the study area, we first employ equivalent source-based field separation technology to eliminate interference from deep-seated sources and adjacent geological bodies, thereby obtaining residual gravity fields at different depths. Meanwhile, various magnitude magnetic transforms (e.g., total magnitude of three magnetic anomalous vector, horizontal total gradient, normalized source strength) are calculated to mitigate the impact of strong remanent magnetization. Subsequently, a comprehensive analysis and evaluation are conducted by integrating geological information, locations of known iron ores, and distributions of density and magnetic susceptibility. The results indicate a strong correspondence between high gravity anomalies and high magnetic anomalies associated with igneous bodies and iron ores, with iron ore occurrences predominantly distributed along the boundaries of high-value zones or transition zones between high and low values of residual gravity anomalies and magnitude magnetic transforms. Finally, prospective areas for iron ores are delineated based on the aforementioned findings, which can provide effective constraints and references based on gravity-magnetic data for subsequent iron ore exploration in the study area.