New soybean variety Hefeng 45 is released by means of sexual hybridization, with female parent suinong 10 and male parent kennong 7. The oil content of this variety is 22.06%, and the protein content is 40.16%. The yield of area test is average of 2920.9 kg/hm2, increasing yield 15.2% compare to CK Hefeng 25. The yield of production test is average of 2826.4kg/hm2, increasing yield 16.4% compare to CK suinong 14. This variety has some good characters such as Disease-resistant, Super-high yield and High oil. It have significant effect to resist Cercospora Sojina Hara, Phytophthoro sojae and Soybean Mosaic Virus. Hefeng 45 spread in 2003. This paper reported the breed selection and experimental results of new soybean variety Hefeng 45, and discussed the key breed technique.