Using quadratic saturation D optimum design method, we studied the effect of different density and N-application rate on maize quality，The results showed that rational close planting and increasing N-application rate can raise maize yield and improve maize quality。By simulated test and optimality selection，we put forward cultivation techniques(maize yield ≥112500kg/hm2 ，coarse starch≥65%, coarse fat ≥4.55%, coarse protein ≥11.2%，lysine≥0.33%，tryptophan≥0.075%)：density is 53475~72435 stubs/hm2，nitrogen-application rate is 278.85~488.70 kg/hm2。