Quantitative structure-property relationship(QSPR) plays a important role in lead structure optimization. It decreases the number of compounds synthesized by facilitating the selection of the most promising examples. The purpose of this paper is to provide a broad overview of the development of QSPR, which will be very useful for development of novel pharmaceuticals. The components involved in the construction of QSPR are reviewed, including discussed various types of structural descriptors and properties, together with techniques to establish correlations between the two.
Key words
Quantitative structure-property relationship;Structural descriptors
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