Common bean (Phaseolus vulgaris) is an important legume vegetable, and its in vitro regeneration is difficult, which limits the efficiency of genetic transformation and molecular breeding. In order to establish an efficient and stable in vitro regeneration system of common bean, this study used ‘Shuangfeng No.1’ common bean as material, cotyledonary nodes, hypocotyls, true leaves and cotyledons as explants, and used direct regeneration (callus pathway) and indirect regeneration (cotyledonary nodes directly bud) to optimize the ratio of plant growth regulators, low temperature and high osmotic stress conditions. The optimal parameters of callus induction, embryogenic callus differentiation, adventitious bud formation and rooting transplanting were systematically screened, and the in vitro regeneration system of common bean was established. The results showed that: (1) the best explants for loose callus induction were hypocotyls and cotyledonary nodes. The best medium was MS+ 1 mg/L 2,4-D, and the induction rates were 93.33% and 90.00%, respectively. (2) The optimal medium for inducing embryogenic callus in common bean（Phaseolus vulgaris）was MS+ 0.5 mg/L 2,4-D+ 0.25 mg/L 6-BA. Embryogenic callus was more easily induced when the explants were cultured at low temperature for 2 to 5 days. However, successful regeneration through callus was not achieved in this experiment, and further research is needed. (3) The indirect regeneration experiment indicated that the best explant was the cotyledon node, and the optimal induction medium was MS+ 2 mg/L 6-BA, with an adventitious bud induction rate of 100%. (4) The induced adventitious buds could be transferred to 1/2 MS+ 1 mg/L IBA rooting medium to regenerate complete plants. The rooting rate was 96.67%, the survival rate of transplanted seedlings was 84.16%, and the regenerated plants could flower and pod normally. This experiment established an efficient in vitro regeneration culture system for common bean (Phaseolus vulgaris), enabling rapid propagation of plants in vitro and laying the foundation for the establishment of a genetic transformation system for common bean (Phaseolus vulgaris).