In order to investigate the effects of aquaculture models on the growth performance and nutritional quality of ‘Liu Yuehuang’ Eriocheir sinensis, healthy buckle crab with body weight of (5.93±0.57) g was selected in outdoor ponds for farming experiments. Two treatment groups were set up: the mixed culture group and the all-male group. A 146-day outdoor cultivation experiment was conducted, after that the growth performance, conventional nutrients, mineral elements, free amino acids and fatty acids across various breeding patterns were tested. The results showed as follows: The final body weight (FBW) and hepatopancreatic index (HSI) of male crabs were higher than those of female crabs. In terms of specific growth rate (SGR) and survival rate (SR), the index of all-male group crabs were 1.84% and 76.40% respectively, while those of mixed-culture group female crabs were 1.75% and 60.19% respectively, and those of mixed-culture group male crabs were 1.78% and 65.52% respectively. The SGR and SR of crabs in the all-male group were significantly higher than those crabs in the mixed culture group (P<0.05). The crude fat content in the hepatopancreas of ‘Liu Yuehuang’ was higher than that of muscle, while the crude protein and water content showed the opposite trend. The calcium contents in the hepatopancreas and muscles of male crabs in the all-male group were 271.44 mg/100g and 215.4 mg/100g respectively, both of which were higher than those in the mixed culture group. The alanine contents in the hepatopancreas and muscles of the all-male group crabs were 0.49 g/100 g and 1.55 g/100 g respectively, while the alanine contents in the same tissues of the mixed-culture group female crabs were 0.40 g/100 g and 1.40 g/100 g respectively, which were significantly lower than those of the all-male group crabs (P<0.05). The contents of docosahexaenoic acid (DHA), total polyunsaturated fatty acid (ΣPUFA), and EPA+DHA in the edible tissues of the all-male experimental crabs were all higher than those of the mixed culture group, but there was no significant difference (P>0.05). It is concluded that the all-male mode of ‘Liu Yuehuang’ could improve their growth performance and nutritional quality, and has a very promising industrial prospect.