The field fertilization experiment, which was conducted in the Danshen Base of Shaanxi Tasly medicine, Plant limited Company in Shangzhu city, Shaanxi province to get the optimum rate of N, P and to known the effect of N, P fertilizer on active ingredient of danshen. The results shown that it was set up the response mathematics equations was set up and analysis the active ingredient (danshentong and danshensu) dynamics change at different growth period. The response equations fertilizer rate of N and P for certain Danshen yields in different soil condition were obtained base on the response mathematics equations of danshen yield with N and P fertilization, the optimum amount of N, P was N127.5~196.7 kg/hm2 and P2O566.55~153.68 kg/hm2 when Danshen target yield at 4500~5000 kg/ hm2, the consequent expressed that N and Pl promoted the Danshen yield exaltation, but is not an using of N and P to more and more needed, if too many N, P fertilizer was used, the output of Danshen would be reduced.