The nucleic acid vaccine has already displayed the strong superiority and vitalities, it develops the foreground huge. Along with the continuously go deep into of the research, the function mechanism of the nucleic acid vaccine also at was constantly clarified. The choice of the outside source purpose gene, the choice of the carrier and the preparative disposal of inoculated organization etc. are all main factors that affects the nucleic acid vaccine to express in the body. Because the nucleic acid vaccine has the advantage that the normal regulations vaccine have no, but the nucleic acid vaccine also exists some problems that didn’t resolve yet. At the same time,. Improve to the nucleic acid vaccine continuously along with the people, we believe that the nucleic acid vaccine will operate the more important function not only under the gene treatment but also under medical in the disease.
Ao Pingxing, Weng Yinbiao, Zhao Ru,Gao Hong, Ao Chengzhuo
. Nucleic Acid Vaccine Current Situation[J]. Chinese Agricultural Science Bulletin, 2005
, 21(3)
: 58
-58
.
DOI: 10.11924/j.issn.1000-6850.050358
1WolffJA,Malliams,etal.Direct gene transfer into mouse muscle in vivo[J].Science,USA,1990,247:146
2潘杰彦,陈薄言.基因免疫的作用机制[J].预防兽医学进展,2003,1(4):20~23
3智海东,童光志.提高基因免疫的机制[J].预防兽医学进展,2000,2(3):33~35
4李光瑞,李惠平,陈娟.DNA疫苗概述[J].中国兽医杂志,1999,25(3):53~54
5许崇波.核酸疫苗研究进展[J].畜牧与兽医,2003,30(4):179~180
6勒家声.核酸―未来的疫苗[J].中国兽医科技,2004,8(11):40~42
7马正海.增强基因疫苗免疫效果的研究进展[J].预防兽医学进展,1999,1(4):27~17
8Montgomery D L.heterologous protection against influenza Aby DNA vaccination:optimization of DNA vector[j].DNA Cell Biologiol,1993,12:777~783
9Davis H L,Brazolet M J,et al.Direct gene transfer in skeletal muscle:plasmid DNA-based immunization against the hepatitis B virus surface against[J].science,USA,1993,259:1745
10Fynan E F. DNA vaccine:protective immunization by parental mucoral and gene-guninoculations,protective Acid [J].science,USA,1993,90:41~56
11周方红.核酸疫苗研究进展[J].预防兽医学进展,1999,1(3):17~20
12Haraharan MJ.DNA immunization against the simplex virus:enhanced efficacy using a sidbis virus-based vector[J].virus,1998,72:950~958
