“Ha Mi” Muskmelon (Var. saccharinus Naud) was grafted on blackseed pumpkin (Cucurbita ficifolia) to control melon fusarium wilt. The effect of graft and seedling on resistance to melon fusarium wilt and on yield and quality were studied. The result demonstrated that there was high affinity between rootstock and scion by different grafting and seedling. The survival rate of grafted plant was above 95%. It also indicated that the grafted plants were better not only in root system, diameter of stem and leaf area, and single fruit weight, yield and quality, but also in their resistance to fusarium wilt. The controlling effectiveness was above 95.4% in field. The seedlings grown in substance were better for grafting as compared with those grown in soil，even better than no-graft. Yield enhancement of grafted melon was mainly in late stage and it enhanced 75.9%-112.3%.