The field experiment was conducted to study the effect of fertilizers N, P, K cooperation on spring wheat growth and yield. The results indicated that fertilizers N、P、K cooperation could promote spring wheat growth. The treatment 2 (N:P2O5:K2O =6:8:3) was most effective among the six fertilization treatments. This showed that wheat dry matter weight and the content of chlorophyll was increased, the activity of NRA and the N content of grain was higher, The character correlation of yield (length per spike, grains per spike, 1000-grain weight)was marked amelioration, the grain yield was highest and was increased 742.6kg/hm2, the rate of increased yield was 18.8%, the quality was good and the content of protein was 804.7kg/hm2.